MPEP 2424.02 Sequence Listing Numeric Identifiers

Manual of Patent Examining Procedure - MPEP

2400 Biotechnology

2424.02 Sequence Listing Numeric Identifiers

37 CFR 1.823(b) sets forth the order and presentation of the items of information in the Sequence Listing. Each item of information in the Sequence Listing must include the appropriate numeric identifier and its accompanying information as shown in the table below. Each item of information must begin on a new line with the numeric identifier enclosed in angle brackets. The submission of those items of information designated with an "M" is mandatory. The submission of those items of information designated with an "O" is optional. Numeric identifiers 110 through 170 must be set forth at the beginning of the Sequence Listing.

The following table illustrates the numeric identifiers. See MPEP § 2431 for a sample Sequence Listing.

Numeric Identifier Definition Comments and format Mandatory (M) or Optional (O)

110 Applicant...................... Preferably max. of 10 names; one name per line; preferable format: Surname, Other Names and/or Initials. M.

120 Title of Invention.......... ............................................................. M.

130 File Reference............... Personal file reference......................... M when filed prior to assignment or appl. number

140 Current Application Number. Specify as: US 07/999,999 or PCT/US96/99999. M, if available.

141 Current Filing Date....... Specify as: yyyy-mm-dd...................... M, if available.

150 Prior Application Number. Specify as: US 07/999,999 or PCT/US96/99999. M, if applicable include priority documents under 35 U.S.C. 119 and 120

151 Prior Application Filing Date. Specify as: yyyy-mm-dd ..................... M, if applicable

160 Number of SEQ ID NOs. Count includes total number of SEQ ID NOs................................................. M.

170 Software....................... Name of software used to create the Sequence Listing. O.

210 SEQ ID NO:#:.............. Response shall be an integer representing the SEQ ID NO shown. M.

211 Length........................... Respond with an integer expressing the number of bases or amino acid residues. M.

212 Type.............................. Whether presented sequence molecule is DNA, RNA, or PRT (protein). If a nucleotide sequence contains both DNA and RNA fragments, the type shall be "DNA." In addition, the combined DNA/ RNA molecule shall be further described in the 220 to 223 feature section. M.

213 Organism...................... Scientific name, i.e. Genus/ species, Unknown or Artificial Sequence. In addition, the "Unknown" or "Artificial Sequence" organisms shall be further described in the 220 to 223 feature section. M.

220 Feature.......................... Leave blank after 220 . 221-223 provide for a description of points of biological significance in the sequence. M, under the following conditions: if "n," "Xaa," or a modified or unusual L-amino acid or modified base was used in a sequence; if ORGANISM is "Artificial Sequence" or "Unknown"; if molecule is combined DNA/RNA.

221 Name/Key..................... Provide appropriate identifier for feature, preferably from WIPO Standard ST.25 (1998), Appendix 2, Tables 5 and 6. M, under the following conditions: if "n," "Xaa," or a modified or unusual L-amino acid or modified base was used in a sequence.

Numeric Identifier Definition Comments and format Mandatory (M) or Optional (O)

222 Location........................ Specify location within sequence; where appropriate state number of first and last bases/amino acids in feature. M, under the following conditions: if "n," "Xaa," or a modified or unusual L-amino acid or modified base was used in a sequence.

223 Other Information......... Other relevant information; four lines maximum............................................. M, under the following conditions: if "n," "Xaa," or a modified or unusual L-amino acid or modified base was used in a sequence; if ORGANISM is "Artificial Sequence" or "Unknown"; if molecule is combined DNA/RNA.

300 Publication Information Leave blank after 300 O.

301 Authors......................... Preferably max. of ten named authors of publication; specify one name per line; preferable format: Surname, Other Names and/or Initials. O.

302 Title............................... ............................................................. O.

303 Journal.......................... ............................................................. O.

304 Volume ......................... ............................................................. O.

305 Issue ............................. ............................................................. O.

306 Pages ............................ ............................................................. O.

307 Date.............. Journal date on which data published; specify as yyyy- mm-dd, MMM-yyyy or Season- yyyy. O.

308 Database Accession Number. Accession number assigned by database including database name. O.

309 Database Entry Date........ Date of entry in database; specify as yyyy-mm-dd or MMM-yyyy. O.

310 Patent Document Number. Document number; for patent-type citations only. Specify as, for example, US 07/ 999,999. O.

311 Patent Filing Date.............. Document filing date, for patent-type citations only; specify as yyyy-mm-dd. O.

312 Publication Date................ Document publication date, for patent-type citations only; specify as yyyy-mm-dd. O.

313 Relevant Residues............ FROM (position) TO (position)........... O.

400 Sequence....................... SEQ ID NO should follow the numeric identifier and should appear on the line preceding the actual sequence. M.

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